The active site structure ofE. coliHPII catalase

PROBING THE ACTIVE SITE OF RHODANESE WITH DISULFIDE REAGENTS

The structure and active site of the Varkud satellite ribozyme.

The Varkud satellite ribozyme is the largest of the small nucleolytic ribozymes, and the only one for which there is no crystal structure. It can be divided into a trans -acting ribozyme, consisting of five helices organized by two three-way helical junctions, and a stem-loop substrate with which it interacts, primarily by tertiary interactions. We have determined the global fold of the ribozym...

Active site structure of the catalase-peroxidases from Mycobacterium tuberculosis and Escherichia coli by extended X-ray absorption fine structure analysis.

The catalase-peroxidase encoded by katG of Mycobacterium tuberculosis is a more effective activator of the antibiotic isoniazid than is the equivalent enzyme from Escherichia coli. The environment of the heme iron was investigated using X-ray absorption spectroscopy to determine if differences in this region were associated with the differences in reactivity. The variation in the distal side Fe...

Structure and Reactivity of the Phosphotriesterase Active Site

The structure and reactivity of the native, mutant, and metal substituted phosphotriesterase (PTE) is determined by ab initio quantum chemistry calculations. The x-ray structure for the Zn-Zn enzyme is leveraged into a catalytically competent active site in which a wide range of theoretical structures can be optimized for metal substituted and mutant active sites. The structural behavior of the...

A Strict Border for the Decidability ofE {

During the execution of functional logic programs, E{unii-cation problems have to be solved quite frequently, where the underlying equational theory is induced by recursive functions. But, what about the decidability of those E{uniication problems? Up to now, there does not exist a concrete answer to this question. In this paper, we answer this question by drawing and verifying a strict border ...